Concurrent Exposure of Neutralizing and Non-neutralizing Epitopes on a Single HIV-1 Envelope Structure
نویسندگان
چکیده
منابع مشابه
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible, fluctuating between closed and more open conformations and sometimes sampling the fully open, CD4-bound form. We hypothesized that conformational flexibility and transient exposure of non-neutralizing, immunodominant epitopes could hinder the induction of broadly neutralizing antibodies (bNAbs). We therefo...
متن کاملNeutralizing Epitopes of HIV-1
Ideally, a vaccine against human immunodeficiency virus type 1 (HIV-1) would induce neutralizing antibody levels which would provide sterilizing immunity. The levels of antibody required however may not be achievable by vaccination (Gauduin et al., 1997; Parren et al., 1997; Moore and Burton, 1999; Shibata et al., 1999). Nevertheless, neutralizing antibody responses albeit of lesser, but still ...
متن کاملNew Insights into Envelope Structure and HIV-specific Neutralizing Antibodies
Designing strategies to foil the ability of HIV to evade neutralizing antibodies represents one of the primary (and still elusive) goals of HIV vaccine research. The crystal structure of HIV-1 gp120 published in 1998 analyzed the conformation of a modified envelope stripped of most of its sugar residues and bound to CD4 and to an antibody that mimicked the chemokine coreceptor binding site (ie,...
متن کاملSpatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit
Ricin toxin's binding subunit (RTB) is a galactose-/N-acetylgalactosamine (Gal/GalNac)-specific lectin that mediates uptake and intracellular trafficking of ricin within mammalian cells. Structurally, RTB consists of two globular domains, each divided into three homologous sub-domains (α, β, γ). In this report, we describe five new murine IgG monoclonal antibodies (mAbs) against RTB: MH3, 8A1, ...
متن کاملCharacterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies.
The entry of human immunodeficiency virus (HIV-1) into target cells typically requires the sequential binding of the viral exterior envelope glycoprotein, gp120, to CD4 and a chemokine receptor. CD4 binding exposes gp120 epitopes recognized by CD4-induced (CD4i) antibodies, which can block virus binding to the chemokine receptor. We identified three new CD4i antibodies from an HIV-1-infected in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2019
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.01512